GOntact

This page allows you to compare the results obtained with GOntact with the results you would obtain with GREAT using the same genomic annotations and the same set of Gene Ontology annotations.

Select the Gene Ontology domain for which you want to compute an enrichment:
biological process
molecular function
cellular component

Select the genome you want to analyze:
human (hg38)
mouse (mm10)

GOntact computes GO enrichments by comparing a foreground set of CREs (e.g. those specifically active in a given biological condition) with a background set of CREs (e.g. CREs detected in a broader set of biological conditions). They have to be provided in bed format, with at least 3 tab-separated fields (chromosome, start position, end position).

Input the coordinates of the foreground CREs (bed format):

(Optional) Input the coordinates of a custom set of background CREs (bed format):

If no background set of CREs is provided, GOntact will compute background GO frequencies based on the whole genome.

Definition of regulatory domains:

Basal regulatory domain, upstream region (bp):
Basal regulatory domain, downstream region (bp):
Regulatory domain extension size (bp):